IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells.? Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties.? These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells.? However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine.? Recombinant Murine IL-1β is a 17.5 kDa protein containing 153 amino acid residues.
Source:
E.coli
Synonyms:
Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
AA Sequence:
MVPIRQLHYR LRDEQQKSLV LSDPYELKAL HLNGQNINQQ VIFSMSFVQG EPSNDKIPVA LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS
Purity:
≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.002 ng/ml, corresponding to a specific activity of ≥ 5 x 108 units/mg.
Note:
1mg will be provided as 2x500μg.
