IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation.? IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response.? IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.? Recombinant Murine IL-2 is a 17.2 kDa protein containing 148 amino acid residues.
Source: E.coli
Synonyms: T-cell growth factor (TCGF), Aldesleukin
AA Sequence: PTSSSTSSST AEAQQQQQQQ QQQQQHLEQL LMDLQELLSR MENYRNLKLP RMLTFKFYLP KQATELKDLQ CLEDELGPLR HVLDLTQSKS FQLEDAENFI SNIRVTVVKL KGSDNTFECQ FDDESATVVD FLRRWIAFCQ SIISTSPQ
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: The ED50 as determined by the dose-dependent stimulation of murine CTLL-2 cells is?≤ 0.2 ng/ml, corresponding to a specific activity of?≥ 5 x 106 units/mg.
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