IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes.? IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNF-α.? Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions.? Human IL-10 is active on murine cells, but murine IL-10 is inactive on human cells.? Recombinant Rat IL-10 is an 18.7 kDa protein of 160 amino acid residues.
Source: E.coli
Synonyms: B-TCGF, CSIF, TGIF
AA Sequence: SKGHSIKGDN NCTHFPVSQT HMLRELRAAF SQVKTFFQKK DQLDNIVLTD SLLQDFKGYL GCQALSEMIK FYLVEVMPQA ENHGPEIKEH LNSLGEKLKT LWIQLRRCHR FLPCENKSKA VEQVKNDFNK LQDKGVYKAM NEFDIFINCI EAYVTLKMKN
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: The ED50 as determined by the dose-dependent inhibition of antigen-specific T cell proliferation is ≤10ng/ml.
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