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PlGF-2? is? an? angiogenic? factor? that? belongs? to? the? cysteine-knot? superfamily? of? growth? factors.??? PlGF-2? is? expressed ?in? umbilical? vein? endothelial? cells? and? placenta.??? It? signals? through? the? VEGFR-1/FLT1? receptor,? and? stimulates? endothelial? cell? proliferation? and? migration.??? PlGF-2? also? signals? through? Neuropilin? (NP-1),? and? can? bind? with ?high? affinity? to? heparin.? Recombinant? Human? PlGF-2? is? a? 34.6? kDa? disulfide-linked? homodimeric? protein? of? two? 152? amino? acid? polypeptide? chains.
Source: E.coli
Synonyms: Placenta Growth Factor-2, PGFL
AA Sequence (monomer): LPAVPPQQWA LSAGNGSSEV EVVPFQEVWG RSYCRALERL VDVVSEYPSE VEHMFSPSCV SLLRCTGCCG DENLHCVPVE TANVTMQLLK IRSGDRPSYV ELTFSQHVRC ECRPLREKMK PERRRPKGRG KRRREKQRPT DCHLCGDAVP RR
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to chemoattract human THP-1 cells of using a concentration range of 5.0-50.0 ng/ml.
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