Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.? The α-defensins, which include NP-1, NP-2 and NP-3, are distinguished from the β-defensins by the pairing of their three disulfide bonds.? In addition to antimicrobial activity, NP-1 exhibits chemotactic activity on dendritic cells.? NP-1 is expressed as the C-terminal portion of an inactive precursor protein, which also contains a 19 amino acid N-terminal signal sequence and a 45 amino acid polypeptide.? NP-1 contains a six-cysteine motif that forms three intra-molecular disulfide bonds.? Recombinant Human NP-1 is a 3.4 kDa protein containing 30 amino acid residues.
Source: E.coli
Synonyms: Neutrophil Peptide-1, alpha Defensin-1, HNP-1, Cryptdin
AA Sequence: ACYCRIPACI AGERRYGTCI YQGRLWAFCC
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to chemoattract immature dendritic cells using a concentration of 1.0-10.0 ng/ml.
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