VEGF is a potent growth and angiogenic cytokine.? It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability.? Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis.? Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes.? VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product.? Recombinant Murine VEGF165 is a 39.0 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.
Manufactured using all Animal-Free reagents.
Source:
E.coli
Synonyms:
Vascular Endothelial Growth Factor165, Folliculostellate cell-derived growth factor, Glioma-derived endothelial cell mitogen, VEGF-A
AA Sequence (monomer):
MAPTTEGEQK SHEVIKFMDV YQRSYCRPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCAGC CNDEALECVP TSESNITMQI MRIKPHQSQH IGEMSFLQHS RCECRPKKDR TKPEKHCEPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR
Purity:
≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by the dose-dependent stimulation of
the proliferation of human umbilical vein endothelial
cells (HUVEC) using a concentration range of 1.0-5.0 ng/ml.
