FGF-4 is a heparin-binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-4 signals through the FGFR 1c, 2c, 3c, and 4. Recombinant Human FGF-4 is a 19.7 kDa protein consisting of 182 amino acid residues.
Source:
E.coli
Synonyms:
Fibroblast Growth Factor-4, HST-1, Transforming protein KS3, HBGF-4
AA Sequence:
GRGGAAAPT APNGTLEAEL ERRWESLVAL SLARLPVAAQ PKEAAVQSGA GDYLLGIKRL RRLYCNVGIG FHLQALPDGR IGGAHADTRD SLLELSPVER GVVSIFGVAS RFFVAMSSKG KLYGSPFFTD ECTFKEILLP NNYNAYESYK YPGMFIALSK NGKTKKGNRV SPTMKVTHFL PRL
Purity:
≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by dose-dependent ability to reduce tetrazolium salt, WST-8, by dehydrogenase activities of BaF3 cells expressing FGF receptors using Cell Counting Kit-8 (CCK-8). The expected ED50 is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Note:
1mg will be provided as 2x500μg.
