ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism.? In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism.? Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ.? ApoE is an important constituent of all plasma lipoproteins.? Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism.? It also binds with the LDL receptor (apo B/E).? Defects in ApoE are a cause of hyperlipoproteinemia type III.? ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution.? E3 is the most common isoform and is present in 40-90% of the population.? Recombinant Human ApoE3 is a 34.0 kDa protein containing 300 amino acid residues.
Source: E.coli
Synonyms: Apoprotein E3
AA Sequence: MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVCGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH
Purity: ≥ 90% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Not available.
Note:
1mg will be provided as 2x500μg.
BIOLEAF熱搜 BIOLEAF試劑盒 BIOLEAF ELISA BIOLEAF試劑 BIOLEAF品牌 BIOLEAF抗體 BIOLEAF耗材 BIOLEAF小儀器
sitemap 細(xì)胞庫查詢 危險(xiǎn)品圖標(biāo) 本公司網(wǎng)站所展示銷售的產(chǎn)品僅供科研！
滬公網(wǎng)安備 31011202007338號
<source id="a42qe"></source>
