Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.? The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6.? β-defensins are expressed on some leukocytes and at epithelial surfaces.? In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.? The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.? β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.? Recombinant Human BD-1 is a 3.9 kDa protein containing 36 amino acid residues.
Source: E.coli
Synonyms: Beta-Defensin 1, DEFB1, HBD1
AA Sequence: DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100.0-1000.0 ng/ml.
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