Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.? The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds.? To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6.? β-defensins are expressed on some leukocytes and at epithelial surfaces.? In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.? The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.? β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.? Recombinant Human BD-2 is a 4.3 kDa protein containing 41 amino acid residues.
Source:
E.coli
Synonyms:
DEFB2, DEFB4A, Beta-Defensin 2, Skin-antimicrobial peptide 1, SAP1
AA Sequence:
GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P
Purity:
≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to chemoattract immature human dendritic cells using a concentration of 10.0-100.0 ng/ml.
