Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.? The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds.? To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6.? β-defensins are expressed on some leukocytes and at epithelial surfaces.? In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.? The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.? β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.? Recombinant Human BD-3 is a 5.1 kDa protein containing 45 amino acid residues.
Source: E.coli
Synonyms: Beta-Defensin 3, DEFB3, DEFB103A
AA Sequence: GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Exhibits antimicrobial activity against gram-positive bacteria S. aureus and gram-negative P. aeruginosa and E.coli.
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