Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system.? The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds.? To date, six human β-defensins have been identified; BD-1, BD-2, BD-3, BD-4, BD-5 and BD-6.? β-defensins are expressed on some leukocytes and at epithelial surfaces.? In addition to their direct antimicrobial activities, they can act as chemoattractants towards immature dendritic cells and memory T cells.? The β-defensin proteins are expressed as the C-terminal portion of precursors, and are released by proteolytic cleavage of a signal sequence and, in some cases, a propeptide sequence.? β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds.?? BD-4 is expressed in the testes, stomach, uterus, neutrophils, thyroid, lungs and kidneys.? In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes.? Recombinant Human BD-4 is a 6.0 kDa protein containing 50 amino acid residues.
Source:
E.coli
Synonyms:
Beta-Defensin 104, DEFB4
AA Sequence:
EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP
Purity:
≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to chemoattract human monocytes using a concentration range of 0.1-100.0 ng/ml.
