IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells.? Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.? IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8.? IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE.? Blocking of IL-13 activity inhibits the pathophysiology of asthma.? Human and murine IL-13 are cross-species reactive.? Recombinant Rat IL-13 is an 11.9 kDa protein consisting of 109 amino acid residues.
Source: E.coli
Synonyms: NC300 (Human), P600 (Murine)
AA Sequence: VRRSTSPPVA LRELIEELSN ITQDQKTSLC NSSIVWSVDI TAGGFCAALE SLTNISSCNA IHRTQRILNG LCNQKASDVA SSPPDTKIEV AQFISKLLNY SKQLFRYGH
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of human TF-1 cells is < 40 ng/ml, corresponding to a specific activity of > 2.5 x 104 units/mg.
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