IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells, CD4+ monocytes, and eosinophils.? Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer.? However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity.? IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells.? Human and murine IL-16 show significant cross-species reactivity.? Recombinant Human IL-16 is a 12.4 kDa protein consisting of 121 amino acid residues.
Source: E.coli
Synonyms: LCF (Lymphocyte Chemoattractant Factor)
AA Sequence: SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QSKETTAAGD S
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to chemoattract human CD4+ T lymphocytes using a concentration range of 50.0-100.0 ng/ml.
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