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Urate Oxidase Recombinant

品牌：Peptides International

貨號：ENZ-312

規(guī)格：100μg

貨期：

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Urate Oxidase Recombinant

商品詳情參考文獻相關(guān)資料

Product Code: ENZ-312
Synonyms/Product Alternate Names: Urate Oxidase, Uricase, Urate Oxygen, Oxidoreductase, UOX, UO, EC 1.7.3.

Urate oxidase catalyzes the enzymatic oxidation (degrades) of uric acid into allantoin, an inactive and soluble metabolite, which is 5 to 10 fold more soluble than uric acid . Urate oxidase is an enzyme of the purine breakdown pathway that catalyses the oxidation of uric acid to allantoin. Uricase is present in numerous diverse organisms, but not in higher primates including human. Hyperuricaemia is most commonly associated with gout and also occurs in mammalians with malignancy, especially those with lymphoid malignancies due to rapid cell turnover and an increased rate of purine metabolism. Uricase is effective in the prevention and treatment of hyperuricaemia in mammalians with malignancy and in those who have undergone transplantation. It appears to act rapidly, safely and induces a more dramatic decrease in plasma levels of uric acid. Oxidase Urate Oxidase Recombinant produced in E.Coli is a tetrameric, non-glycosylated polypeptide chain containing 302 amino acids, having a molecular formula of C1523H2383N417O462S7 and a molecular mass of 34,247 Dalton. The cDNA coding for urate-oxidase was cloned from a strain of Aspergillus flavus . The monomer protein has no intra- or inter-disulfide bridges. Each 1.5mg Uricase contains 5mg sucrose, 25mg glycine, 0.1mg Tween-80, 13.6 mg Na2HPO4*12H20 and 0.33 mg NaH2PO4*2H20. The specific activity was found to be 10U/mg. One Unit oxidizes one micromole of uric acid per minute at 25°C, at pH 8.5.
Storage Conditions: -20 °C
Molecular Weight: 34,247 Dalton
Molecular Formula: C₁₅₂₃H₂₃₈₃N₄₁₇O₄₆₂S₇
One-Letter Code:
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