Epidermal Growth Factor (EGF) EGF is a 6-kDa protein consisting of 53 amino acids residues with three intermolecular disulfide bonds. It was originally isolated from the sub-maxillary glands of mice by Cohen. EGF stimulates the cell proliferation and differentiation by binding the receptor EGFR.
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R.H. Starkey, S. Cohen, and D.N. Orth, Science, 189, 800 (1975).
S. Cohen and G. Carpenter, Proc. Natl. Acad. Sci. U.S.A., 72, 1317 (1975).
H. Gregory, Nature, 257, 325 (1975).
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