PYY (3-36), a Y2 receptor agonist, is released from the body's gastrointestinal tract in proportion to caloric intake. It has been shown that peripheral injection of PYY (3-36) in rats inhibited food intake and reduced weight gain. In addition, infusion of PYY (3-36) in humans significantly decreased appetite and reduced food intake by 33% over 24h, which suggests that PYY (3-36) has a role in 'longer term' regulation of food intake. Thus, the PYY (3-36) may represent a lead compound for the development of drugs for the treatment of obesity.
R.L.Batterham et al., N. Engl. J. Med., 349, 941 (2003).
I.G.Halatchev and R.D.Cone, Cell Metab., 1, 159 (2005)
PK Chelikani, et al, Am. J Phyiol Regul Integr Comp Physiol,, 293, R39, (2007).
G.H.Ballantyne, Obes. Surg., 16, 651 (2006).
C.Acuna-Goycolea and A.N.van den Pol, J. Neurosci., 25, 10510 (2005).
Y.Shechter et al., FEBS Lett., 579, 2439 (2005).
R.L.Batterham et al., Nature, 418, 650 (2002).
D.Grandt et al., Regul. Peptides, 40, 161 (1992).
BIOLEAF熱搜 BIOLEAF試劑盒 BIOLEAF ELISA BIOLEAF試劑 BIOLEAF品牌 BIOLEAF抗體 BIOLEAF耗材 BIOLEAF小儀器
sitemap 細(xì)胞庫查詢 危險(xiǎn)品圖標(biāo) 本公司網(wǎng)站所展示銷售的產(chǎn)品僅供科研!
滬公網(wǎng)安備 31011202007338號(hào)