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L-type Ca2+ channel (Cav1.2) (pSer1928) pAb

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L-type Ca2+ channel (Cav1.2) (pSer1928) pAb

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L-type Ca2+ channel (Cav1.2) (pSer1928) pAb

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L-type Ca2+ channel (Cav1.2) (pSer1928) pAb

$599.00

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Product code: A010-70
Unit Size: 50 μl

A well validated rabbit polyclonal antibody specific to Serine-1928 phosphorylated Cav1.2 (α1c sub-unit of L-type Ca2+channel)

Background: The L-type Ca²⁺ channel (LTCC, or Cav1.2 or dihydropyridine receptor) is a voltage gated Ca²⁺ channel of the plasma membrane in brain and heart, which is responsible for the influx of Ca²⁺ to initiate neurotransmitter release (in neurones) or muscle contraction (in cardiac muscle). The channel is controlled by a number of chemical influences including phosphorylation on Ser-1928 by PKA which enhances ion channel activity. Ser-1928 from rabbit, is conserved across all mammalian species and is thought to be phosphorylated in response to elevated cAMP in these species.

Tested applications: IHC Microscopy (1:100). Species recognition: all mammalian species, when phosphorylated on Ser-1928.

Description	Lyophilised rabbit polyclonal anti-serum (A010-70) containing IgG antibody specific for Cav1.2 Phospho Ser-1928 (PKA site).
Immunogen	Synthetic peptide (LGRRAS(PO3H2)FHLE1932) corresponding to amino acids surrounding the phosphorylated serine residue at position 1928 of α1c subunit of Cav1.2 from rabbit conjugated to KLH.
Isotype	IgG
Purification	Raw serum
Species reactivity	The epitope peptide aligns exactly to Human Cav1.2 α1c isoforms 1-23 (See website - Ep/Is alignment). The antibody has been shown to recognise phosphorylated serine-1928 of rat Cav1.2 (α1c), and binding is blocked in the presence of a peptide containing the Phospho Ser-1928 epitope.
Tested applications	IHC microscopy
Recommended dilution	IHC microscopy: 1:100
Optimization	Optimal dilutions to be determined by end user
Storage	Lyophilised antibody is stable at 4°C when stored with desiccant. Reconstitute lyophilised powder in 50 μl of 18 MΩ H2O, aliquot and store frozen at -80°C for 1 year. Avoid freeze - thaw cycles.
Storage	Lyophilised: 4 °C. Reconstituted:-80 °C
Datasheet	A010-70
MSDS	A010-70
Regulatory statement	Product for research use only. Not intended for diagnostic or therapeutic use.