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CaMKII (pThr286 or 287) pAb

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CaMKII (pThr286 or 287) pAb

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CaMKII (pThr286 or 287) pAb

$325.00

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Product code: A010-50AP
Unit Size: 50 μl

A fully validated, highly specific affinity purified rabbit polyclonal antibody to α and β isoforms of threonine-286 phosphorylated CaMKII

Ca²⁺/calmodulin-dependent kinase II (CaMKII) is a ubiquitous, multifunctional serine/threonine kinase involved in translating Ca²⁺- transient signals into cellular responses. Four separate CaMKII genes are expressed in man (α, β, δ, γ) with isoforms within each gene. CaMKII δ and γ are abundant in the heart. CaMKII is activated by Ca²⁺/CaM binding, and becomes activated for prolonged periods of time following autophosphorylation of Thr-286 or Thr-287 (equivalent residues in different isoforms). This antibody recognizes the active, autophosphorylated enzyme (all isoforms) and thus can measure the abundance of active CaMKII. Prolonged activation of CaMKII is associated with a variety of vascular and cardiac diseases including stroke, atrial fibrillation cardiac arrhythmia & sudden death, cardiac apoptosis, and heart failure.

Antibody form: Lyophilised Protein A Affinity Purified Antibody (IgG). Species recognition: rat, human and mouse. Expected to react with various isoforms from chicken, cow, pig, rabbit, orangutan, zebrafish, ferret and Xenopus laevis.

Description	Affinity purified rabbit polyclonal antibody to CaMKII phospho threonine-286/287
Immunogen	Synthetic peptide (M281HRQET(PO3H2)VDC289) corresponding to amino acids surrounding the phosphorylated threonine residue at position 286 or 287 of CaMKII, which was conjugated to keyhole limpet hemocyanin (KLH) by carbodiimide cross linkage.
Isotype	IgG
Purification	Protein A affinity purified
Species reactivity	Reacts with rat. Not yet tested in other species. However, from primary sequence analysis, the antibody will recognise Phospho Thr-286 (or 287) in all isoforms (α, β, γ and δ) from human, rat and mouse. The antibody is also expected to react with various isoforms from chicken, cow, pig, rabbit, orangutan, zebrafish, ferret and Xenopus laevis.
Tested applications	WB
Recommended dilution	WB 1:1000
Optimization	Optimal dilutions to be determined by end user
Storage	Lyophilised antibody is stable at 4°C when stored with desiccant. Reconstitute lyophilised powder in 50 μl of 18 MΩ H2O, aliquot and store frozen at -80°C for 1 year. Avoid freeze - thaw cycles.
Storage	Lyophilised: 4°C. Reconstituted:-80°C
Datasheet	A010-50AP
MSDS	A010-50AP
Regulatory statement	Product for research use only. Not intended for diagnostic or therapeutic use.