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The ryanodine receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of Ca2+ to RyR2 opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction. PKA, and not CaMKII, was able to phosphorylate Ser-2030 of RYR2 in vitro and in isolated cardiac myocyte cells.
Tested applications: Western blot (1:5000 dilution). Species recognition: human, rat, mouse, rabbit, canine and sheep.
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