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Ryanodine receptor 2 (RYR2) (pSer2814) pAb

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Ryanodine receptor 2 (RYR2) (pSer2814) pAb

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Ryanodine receptor 2 (RYR2) (pSer2814) pAb

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Ryanodine receptor 2 (RYR2) (pSer2814) pAb

$655.00

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Product code: A010-31AP
Unit Size: 100 μl

A fully validated, highly specific affinity purified rabbit polyclonal antibody to Serine-2814 phosphorylated Ryanodine Receptor

The Ryanodine Receptor (RyR2) is a Ca2+ channel of cardiac muscle that plays a central role in EC coupling. The binding of Ca2+ to ryanodine receptor 2 RyR2 opens the channel and Ca2+ stored in the SR moves through the channel into the cytosol to initiate muscle contraction. CaMKII, was able to phosphorylate Ser-2814 of RYR2 enhancing Ca2+- sensitivity and increasing open probability. Excessive phosphorylation of Ser-2814 leads to atrial fibrillation, arrhythmias and sudden death.

Tested applications: Western blot (1:1000 dilution). Species recognition: All mammalian species, when phosphorylated on Ser-2814 (or Ser-2815 rabbit).

Description	Lyophilised rabbit polyclonal IgG antibody (A010-31AP) specific to RyR2 phospho ser-2814
Immunogen	Synthetic peptide (TSQVS(PO3H2)VDAAH2819) corresponding to amino acids surrounding the phosphorylated serine residue at position 2814 of RyR2 (human) conjugated to KLH.
Isotype	IgG
Purification	Protein A affinity purified
Species reactivity	Dog, mouse, human: despite minor differences in sequence, this antibody interacts with antigen based on the human and mouse sequence.
Tested applications	WB. Not yet tested in other applications, therefore, optimal dilutions/concentrations should be determined by the user. Also effective in ELISA and IHC microscopy.
Recommended dilution	WB 1:1000
Optimization	Optimal dilutions to be determined by end user
Storage	Lyophilised antibody is stable at 4°C when stored with desiccant. Reconstitute lyophilised powder in 100 μl of 18 MΩ H2O, aliquot and store frozen at -80°C for 1 year. Avoid freeze - thaw cycles.
Storage	Lyophilised: 4 °C Reconstituted:-80 °C
Datasheet	A010-31AP Lot 0611-03 A010-31AP Lot 0314-01
MSDS	A010-31AP >
Regulatory statement	Product for research use only. Not intended for diagnostic or therapeutic use.