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β-Dystroglycan (bDG) (pTyr892) pAb serum

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β-Dystroglycan (bDG) (pTyr892) pAb serum

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β-Dystroglycan (bDG) (pTyr892) pAb serum

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β-Dystroglycan (bDG) (pTyr892) pAb serum

$325.00

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Product code: A010-200
Unit Size: 100 μl

A fully validated, highly specific rabbit polyclonal anti-serum to Tyrosine-892 phosphorylated forms of β-dystroglycan

43kDa Dystrophin-associated glycoprotein; (43-DAG, DG, b-DAG, b -DG, DAG1) β-dystroglycan is a component of the dystrophin glycoprotein complex (DGC), a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle and other tissues (Winder 2001). It is a transmembrane protein (single TM domain) of 34.9kDa molecular weight, and pI 8.85, which displays an apparent molecular weight of 43kDa by SDS-PAGE due to asparagine-linked glycosylation and a high proportion of proline residues in the cytoplasmic domain. The dystroglycan complex is a subcomplex within the DGC comprising alpha and beta-subunits. Dystroglycan is of importance in cell signalling, cell polarity, cell adhesion and movement. β-dystroglycan binds to dystrophin (in muscle cells) and utrophin (in non-muscle cells), but dissociates from these proteins when phosphorylated on Tyr-892 allowing its association with SH2 containing proteins such as Src and other cytolinker proteins such as plectin. This antibody recognises Tyr-892 phosphorylated forms of β-dystroglycan (Tyr-892 in human, Tyr-890 in mouse)

Tested applications: Western blot (1:500 dilution), IHC Microscopy (1:50 dilution), Immunoprecipitation (1:10 dilution) in RIPA buffer. Species recognition: recognises β-dystroglycan in all mammalian species, when phosphorylated on Tyr-892 (or equivalent).

Description	Lyophilised rabbit polyclonal anti-serum containing antibody specific for Tyr-892 phosphorylated forms of β-dystroglycan
Immunogen	Phosphopeptide comprising residues 983-994 (residues MTPYRSPPPY(PO3H2)VP) conjugated to KLH.
Isotype	IgG
Purification	Raw serum
Species reactivity	Recognises β-dystroglycan in all mammalian species, when phosphorylated on Tyr-892 (or equivalent).
Tested applications	WB, IH, IP
Recommended dilution	WB: 1:500, IH 1:50, IP 1:10 (in RIPA buffer)
Optimization	Optimal dilutions to be determined by end user
Storage	Lyophilised antibody is stable at 4°C when stored with desiccant. Reconstitute lyophilised powder in 100 μl of 18 MΩ H2O, aliquot and store frozen at -80°C for 1 year. Avoid freeze - thaw cycles.
Storage	Lyophilised: 4 °C. Reconstituted:-80 °C
Datasheet	A010-200
MSDS	A010-200
Regulatory statement	Product for research use only. Not intended for diagnostic or therapeutic use.