In stock
Phospholamban (PLB/PLN) is a small transmembrane protein which plays an important role in controlling the activity of the sarcoplasmic reticulum ATPase (SERCA2a) of cardiac muscle during calcium sequestration.
Phospholamban is phosphorylated on separate amino acid residues by cAMP-dependent, and cGMP-dependent (serine-16) and Ca2+/CaM-dependent (threonine-17) protein kinases in response to β-adrenergic stimulation. Akt has also been shown to phosphorylate Thr-17. The result is an increased calcium pump activity which reduces the time course of the calcium transient, increases the calcium load in the sarcoplasmic reticulum, and consequently, produces a larger calcium transient at the next action potential. However, alteration in this homeostatic interaction has been shown to result in heart failure.
Tested applications: Western blot (1:5000 dilution). Supplied as lyophilised affinity purified IgG.
BIOLEAF熱搜 BIOLEAF試劑盒 BIOLEAF ELISA BIOLEAF試劑 BIOLEAF品牌 BIOLEAF抗體 BIOLEAF耗材 BIOLEAF小儀器
sitemap 細胞庫查詢 危險品圖標 本公司網(wǎng)站所展示銷售的產品僅供科研！
滬公網(wǎng)安備 31011202007338號