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Phospholamban (PLN, PLB) (pSer16) pAb serum

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Phospholamban (PLN, PLB) (pSer16) pAb serum

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Phospholamban (PLN, PLB) (pSer16) pAb serum

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Phospholamban (PLN, PLB) (pSer16) pAb serum

$325.00

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Product code: A010-12
Unit Size: 25 μl

A fully validated, highly specific polyclonal antiserum to Serine-16 phosphorylated forms of phospholamban

Background: Phospholamban (PLB/PLN) is a small transmembrane protein which plays an important role in controlling the activity of the sarcoplasmic reticulum ATPase (SERCA2a) of cardiac muscle during calcium sequestration. Phospholamban is phosphorylated on separate amino acid residues by cAMP-dependent, and cGMP-dependent (Ser-16) and Ca²⁺/CaM-dependent (Thr-17) protein kinases in response to β-adrenergic stimulation. Akt has also been shown to phosphorylate Thr-17. The result is an increased calcium pump activity which reduces the time course of the calcium transient, increases the calcium load in the sarcoplasmic reticulum, and consequently, produces a larger calcium transient at the next action potential. However, alteration in this homeostatic interaction has been shown to result in heart failure

Tested applications: Western Blot (1:5000 dilution), ELISA. Species recognition: all mammalian species, when phosphorylated on Ser-16.

Description	Lyophilised Rabbit polyclonal anti-serum (A010-12) containing IgG antibody specific for Ser-16 phosphorylated forms of PLB (Drago & Colyer, 1994).
Immunogen	Phosphopeptide comprising residues 9-19-Y (residues R9SAIRRAS(PO3H2)TIE19Y) conjugated to KLH.
Isotype	IgG
Purification	Raw serum
Species reactivity	The antibody recognises mono and oligomeric phospholamban when phosphorylated on serine-16 by PKA. Binding of the antibody to its target epitope is blocked in the presence of a phosphopeptide containing the PLB Phospho Ser-16 epitope. Antibody affinity is reduced in circumstances of dual phosphorylation of Ser-16 and Thr-17.
Tested applications	WB, ELISA and IHC microscopy
Recommended dilution	WB 1:5000
Optimization	Optimal dilutions to be determined by end user
Storage	Lyophilised antibody is stable at 4 °C when stored with desiccant. Reconstitute lyophilised powder in 25 μl of 18 MΩ H2O, aliquot and store frozen at -80 °C for 1 year. Avoid freeze - thaw cycles.
Storage	Lyophilised: 4 °C Reconstituted:-80 °C
Datasheet	A010-12
MSDS	A010-12
Regulatory statement	Product for research use only. Not intended for diagnostic or therapeutic use.