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Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody

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Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody

品牌：Abmgood

貨號：Y052138

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Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody

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Overview	Print Version
Product Name	Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody
Description	EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial to maintaining a normal balance in cell growth and development. Growth factor receptors are involved not only in promoting the proliferation of normal cells but also in the aberrant growth of many types of human tumors. For example, the epidermal growth factor receptor (EGFR) is mutated and/or over-expressed in many common solid human squamous cell carcinomas including breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. Overexpression of the EGFR gene occurs in carcinomas with and without gene amplification. EGFR and ErbB-2 are particularly important in breast cancer because increased production or activation has been associated with poor prognosis. EGFR belongs to a family of growth factor receptors, which also includes ErbB-2/HER-2/neu, ErbB-3/HER-3/neu and ErbB- 4/HER-4/neu. EGFR can heterodimerize with each of the members of this family.
Subtype	polyclonal
Application	WB, IP, ELISA
Raised In	rabbit
Specificity	This antiserum is directed against human epidermal growth factor receptor (EGFR) and is useful in determining its presence in western blotting and immunoprecipitation experiments. This antibody can detect EGFR from human, mouse and rat sources. Reactivity of this antibody with EGFR from other species is unknown.
Immunogen	This whole rabbit serum was prepared by repeated immunizations with a peptide synthesized using conventional technology. The sequence of the epitope maps to a region near the carboxy terminus which is identical in human, mouse and rat EGFR.
Guarantee	abm guarantees that all our Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody will perform as described on this product webpage, if this is not the case we will provide you with a one-time replacement at no extra cost. Documentation and explanation of experiment conducted will be required when submitting a claim for replacement.
Properties
Formulation	Liquid
Quantity	100 μl
Clone	Polyclonal
Storage	This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Storage Buffer	PBS, pH 7.4 with 0.05% sodium azide.
Concentration	1μg/ul
Purity	Purified
Isotype	IgG
Species Reactivity	human, mouse, rat
Anti-Human Epidermal Growth Factor Receptor (EGFR) Antibody Images


Specific References
Y052138 has been referenced in 1 publication. Sartor, C.I., et al. (1997) The Role of EGF Receptor and STAT-3 Activation in Autonomous Proliferation of SUM-102PT Human Breast Cancer Cells. Cancer Research 57:978. Scambia, G., et al. (1993) Expression of ras oncogene p21 protein in normal and neoplastic ovarian tissues: Correlation with histopathological features and receptors for estrogen, progesterone, and the epidermal growth factor. Am. J. Obstet. Gynecol. 168:71-78. Henzen-Logmans, S.C., et al. (1993) Occurrence of epidermal growth factor receeptors in benign and malignant ovarian tumors and normal ovarian tissues: an immunohistochemical study. J. Can. Res. Clin. Oncol. 188:303-307. Sibilia, M., et al. (2000). The EGF Receptor Provides an Essential Survival Signal for SOS-Dependent Skin Tumor Development. Cell 102:211-220.