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A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 (Cat. No. 1570-5) that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.

Additional Information

Synonyms	(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
Product #	W-2483
CAS #	857064-38-1
Chemical Name	(2E)-3-(6-Bromo-2-pyridinyl)-2-cyano-N-[(1S)-1-phenylethy]-2-propenamide
Formula	C17H14BrN3O
MW	356.22
Appearance	Off-White Solid
Purity	97% by HPLC
Solubility	DMSO (10 mg/ml) and Ethanol (5 mg/ml)
Melting Point	218.49 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A cell permeable inhibitor of STAT3 and JAK-2 protein tyrosine kinase is a potent antitumor agent

Additional Information

MDL Number	MFCD12912450
ChemACX	X4738791-5
InChI	InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
SMILES	C[C@@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=NC(=CC=C2)Br)/C#N