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A pre-prodrug of 5-fluorouracil (5-FU).? After oral uptake, capecitabine is first metabolized to 5'-deoxy-5-fluorocytidine (5'-DFCR), which occurs mainly in the liver by carboxyl-esterase.? The metabolite is converted to 5'-deoxy-5-fluoro-uridine (5'-DFUR) by cytidine deaminase in liver and tumor tissue.? Then 5'-DFUR is converted to 5-FU intracellularly by thymidine phosphorylase, which is often expressed in tumor tissue.

Additional Information

Product #	C-2217
CAS #	154361-50-9
Chemical Name	Pentyl[1-(3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl)- 5-fluoro-2-oxo-1H-pyrimidin- 4-yl]aminomethanoate; captabin; Ro 09-1978; Xabine
Formula	C15H22FN3O6
MW	359.35
Appearance	White to off-white solid
Purity	≥99% by HPLC
Solubility	DMSO (100 mg/ml) or EtOH (10 mg/ml)
Storage Temp	-20°C

Additional Information