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Calpain Inhibitor II is a cell-permeable, peptide aldehyde inhibitor of calpain I?(Ki=190nM), calpain II?(C-1259)(Ki=150nM),?cathepsin B,?cathepsin L?(Ki=0.5nM) and other neutral cysteine proteases. Calpain Inhibitor II inhibits?cell cycle progression at G1/S and metaphase/anaphase in?CHO cells by inhibiting cyclin B degradation. Also stimulates?HMG-CoA synthase transcription by inhibiting degradation of?active SREBP-1 (sterol regulatory element-binding protein 1).?Protects against neuronal damage caused by hypoxia and?ischemia.

Calpain Inhibitor II inhibits apoptosis in thymocytes and?metamyelocytes. Also prevents nitric oxide production by?activated macrophages by interfering with the transcription?of inducible nitric oxide synthase (iNOS; NOS II). Inhibits?proteolytic degradation of IκBα and IκB? in RAW?macrophages induced with LPS. It also prolong association?of MHC class I molecules with the transporters associated?with antigen processing.

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