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Artemisinin

品牌：AG Scientific

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規(guī)格：1 g

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CAS:63968-64-9Formula:C15H22O5MW:282.4Appearance:Whiteneedle-likecrystalsPurity:98%byHPLC

商品詳情參考文獻(xiàn) 相關(guān)資料

Artemisinin is an antimalarial drug. It is an endoperoxide sesquiterpene lactone isolated from the aerial parts of Artemisia annua. Artemisinin is a chemical compound that reacts with iron to form free radicals which can kill cells. Cancer cells are more susceptible to the cytotoxic effect of artemisinin than normal cells. Studies have suggested that artemisinin-tagged transferrin is highly selective and potent in killing cancer cells. Thus, artemisinin and artemisinin-tagged iron-carrying compounds could be developed into powerful anticancer drugs.

References:

.Development of artemisinin compounds for cancer treatment.?-?Lai HC1,?Singh NP,?Sasaki T.

Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds. -?Lai H1,?Sasaki T,?Singh NP.

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Additional Information

Synonyms	Arteannuin, Qinghosu, Huanghuanhaosu
Product #	A-2426
CAS #	63968-64-9
Chemical Name	(3R, 5aS, 6R, 8aS, 9R, 12S, 12aR)- Octahydro-3, 6, 9-trimethyl-3, 12-epoxy-12H-pyrano (4, 3-j)-1, 2-benzodioxepin-10(3H)-one
Formula	C₁₅H₂₂O₅
MW	282.4
Appearance	White needle-like crystals
Purity	98% by HPLC
Solubility	Soluble in 10mg/ml Methanol, or 10mg/ml DMSO, or 10mg/ml Ethyl Acetate, all giving clear colorless solution. ?Soluble in Methanol, Ethanol (up to 1.5%), w/v, DMF, DMSO, acetone; Ethyl Acetate: up to 10% w/v, Almost insoluble in water (<100mg/L)
Melting Point	150°C
Storage Temp	-18°C
Therapeutic Area	Infectious Diseases
Use	An antimalarial agent that inhibits VEGF expression and NOS2

Additional Information

Merck Index	Merck Index 14: 817
MDL Number	MFCD00081057
ChemACX	X1009651-4
InChI	InChI=1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14-,15-/m1/s1
SMILES	C[C@@H]1CC[C@H]2[C@H](C(=O)O[C@H]3[C@@]24[C@H]1CCC(O3)(OO4)C)C