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Sunitinib malate

品牌：AG Scientific

貨號：

規(guī)格：25 mg

貨期：

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CAS:341031-54-7Formula:C22H27FN4O2.C4H6O5MW:532.56Appearance:Yellow-orangePowderPurity:99%byHPLC

商品詳情參考文獻(xiàn) 相關(guān)資料

Sunitinib is a potent inhibitor of CSF-1 receptor kinase in an enzyme assay, with an ICof 7 nM, and inhibits receptor phosphorylation in a cellular assay with an ICof 61 nM. Sunitinib inhibits SCF-induced phosphotyrosine levels on KIT (IC= 1 - 10 nM) and reduced SCF-stimulated ERK1/2 phosphorylation with an ICvalue consistent with that for inhibition of KIT phosphotyrosine levels. Sunitinib also inhibited SCF-stimulated proliferation in NCI-H526 cells (IC= 2 nM).

Additional Information

Synonyms	SU-11248, Sutent, PHA-290940AD, PNU-290940AD
Product #	S-2448
CAS #	341031-54-7
Chemical Name	(Z)-N-(2-(DIETHYLAMINO)ETHYL)-5-((5-FLUORO-2-OXOINDOLIN-3-YLIDENE)METHYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE (S)-2-HYDROXYSUCCINATE
Formula	C₂₂H₂₇FN₄O₂.C₄H₆O₅
MW	532.56
Appearance	Yellow-orange Powder
Purity	99% by HPLC
Solubility	DMSO (40 mg/ml)
Melting Point	185-192 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Sunitiba Malate is an antineoplastic agent and a potent RTK inhibitor which includes Flk-1 (VEGFR2)?

Additional Information

MDL Number	MFCD08282795
ChemACX	X1599135-2
InChI	InChI=1S/C22H27FN4O2.C4H6O5/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28;5-2(4(8)9)1-3(6)7/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28);2,5H,1H2,(H,6,7)(H,8,9)/b17-12-;/t;2-/m.0/s1
SMILES	CCN(CC)CCNC(=O)c1c(c([nH]c1C)/C=C2/c3cc(ccc3NC2=O)F)C.C([C@@H](C(=O)O)O)C(=O)O

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