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Compound 401

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CAS:168425-64-7Formula:C16H15N3O2MW:281.31Appearance:Whitetooff-whiteSolidPurity:97%byHPLC

商品詳情參考文獻相關(guān)資料

Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC= 0.28 M) that also targets mTOR (IC= 5. 3M), but not PI 3-K in vitro. Induces apoptosis in vitro.

Additional Information

Synonyms	2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
Product #	C-2268
CAS #	168425-64-7
Chemical Name	2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one
Formula	C₁₆H₁₅N₃O₂
MW	281.31
Appearance	White to off-white Solid
Purity	97% by HPLC
Solubility	Soluble in DMSO (10 mM) or EtOH (5 mM)
Melting Point	187.05 °C
Storage Temp	+4°C
Therapeutic Area	Oncological Disorders
Use	Reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR)

Additional Information

MDL Number	MFCD10568147
ChemACX	X1763989-1
InChI	InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2
SMILES	C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2

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