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Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC₅₀ = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits protein kinase A (PKA) (IC₅₀ = 0.9 μM) and calcium/calmodulin kinase II (IC₅₀ = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC₅₀ = 6.8 nM).

Additional Information

Synonyms	BIM IX; Ro 31-8220 methanesulfonate
Product #	R-2418
CAS #	138489-18-6
Chemical Name	2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate
Formula	C25H23N5O2S.CH4O3S
MW	553.65
Appearance	Red solid
Purity	≥98% by NMR
Solubility	DMSO (~ 100 mg/ml) or water (~ 5 mg/ml)
Storage Temp	-20°C

Additional Information