Bacitracin is a unique cyclic polypeptide antibiotic produced by Bacillus subtilis. ?
Bacitracin is comprised of numerous antimicrobial peptide fractions. Notable fractions include A, A1, B, B1, B2, C, D, E, F, G, and X. Standard grade bacitracin (B002) is a mixture of these fractions. Bacitracin A has been found to have the most antibacterial activity. Bacitracins B1 and B2 together have a similar antibacterial potency (approx. 90% of bacitracin A). Other bacitracin fractions including bacitracin F and bacitracin Xa have not been studied extensively; however, they appear to have negligible antibacterial activity.
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