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Aurora Kinase B Inhibitor (AZD1152-HQPA)

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Aurora Kinase B Inhibitor (AZD1152-HQPA)

品牌：AG Scientific

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規(guī)格：5 mg

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CAS:722544-51-6Formula:C26H30FN7O3MW:507.56Appearance:CrystallineSolidPurity:99%byHPLC

商品詳情參考文獻相關(guān)資料

A potent and specific Aurora kinase B inhibitor. It is 1000-fold more selective for aurora kinase B than for aurora kinase A ( Ki values of 1300 nM and 0.36 nM for aurora kinase A and B, respectively). At concentrations as low as 0.01 M, AZD 1152 produced a significant (p<0.05) decrease in the ability of NB4 cells to proliferate by 48 hours.

Additional Information

Synonyms	AZD1152-HQPA
Product #	A-2192
CAS #	722544-51-6
Chemical Name	3-[[7-[3-[ETHYL(2-HYDROXYETHYL)AMINO]PROPOXY]-4-QUINAZOLINYL]AMINO]-N-(3-FLUOROPHENYL)-1H-PYRAZOLE-5-ACETAMIDE
Formula	C₂₆H₃₀FN₇O₃
MW	507.56
Appearance	Crystalline Solid
Purity	99% by HPLC
Solubility	DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A potent and specific Aurora kinase B inhibitor use in pancreatic and colon cancer

Additional Information

MDL Number	MFCD10687152
ChemACX	X1812315-4
InChI	InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
SMILES	CCN(CCCOc1ccc2c(c1)ncnc2Nc3cc([nH]n3)CC(=O)Nc4cccc(c4)F)CCO

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