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Cell-permeable. A synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1.

Additional Information

Synonyms	1,5-Dihydro-5-methyl-1-b-D-ribofuranosyl-1,2,5,6,8-pentaazanaphthylen-3-amine; NSC 154020
Product #	T-2467
CAS #	35943-35-2
Chemical Name	1,5-Dihydro-5-methyl-1-b-D-ribofuranosyl-1,2,5,6,8-pentaazanaphthylen-3-amine; NSC 154020
Formula	C13H16N6O4
MW	320.3
Appearance	Pale yellow Solid
Purity	98% by HPLC
Solubility	DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Triciribine, also known as API-2, suppresses the phosphorylation level and kinase activity of Akt

Additional Information

MDL Number	MFCD00932413
ChemACX	X1035902-9
InChI	InChI=1S/C13H16N6O4/c1-18-11-7-5(10(14)17-18)2-19(12(7)16-4-15-11)13-9(22)8(21)6(3-20)23-13/h2,4,6,8-9,13,20-22H,3H2,1H3,(H2,14,17)/t6-,8-,9-,13-/m1/s1
SMILES	CN1c2c3c(cn(c3ncn2)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)C(=N1)N