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Thapsigargin, ER stress inducer

品牌：AG Scientific

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規(guī)格：1 mg

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CAS:67526-95-8Formula:C34H50O12MW:650.8Appearance:Whitetooff-whitelyophilizedpowderPurity:99.8%

商品詳情參考文獻(xiàn) 相關(guān)資料

Thapsigargin?is a specific inhibitor of the sarcoplasmic/endoplasmic reticulum?Ca2+-ATPase?(SERCA).?Thapsigargin?increases cytosolic?calcium?levels through release from intracellular?calcium?stores. Depletion of ER calcium stores leads to Ca²⁺?influx via activation of?store (voltage)-operated calcium channels?in the?plasma membrane, mediating numerous physiological functions, including?exocytosis,?chemotaxis, transcription,?cell division, and?apoptosis.?There are preclinical indications that the drug may have?anticancer?potential.

According to a recent paper Thapsigargin indirectly and robustly inhibits nonsense-mediated RNA decay (NMD), and this potential of thapsigargin has been harnessed to develop a method that detects NMD efficiency inside the cell.

Additional Information

Synonyms	thaps, tg
Product #	T-1014
CAS #	67526-95-8
Chemical Name	[(3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-ACETYLOXY-4-BUTANOYLOXY-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-[(Z)-2-METHYLBUT-2-ENOYL]OXY-2-OXO-4,5,6A,7,8,9B-HEXAHYDROAZULENO[4,5-B]FURAN-7-YL] OCTANOATE
Formula	C₃₄H₅₀O₁₂
MW	650.8
Appearance	White to off-white lyophilized powder
Purity	99.8%
Solubility	Clear and colorless solution at 10 mg/mL of CH₃CN
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase

Additional Information

Merck Index	Merck Index: 13.9342
MDL Number	MFCD00083511
ChemACX	X1096797-0
InChI	InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
SMILES	CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=CC)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O