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Cell-permeable. An oxindole derivative that acts as a potent, reversible, and ATP-competitive Spleen tyrosine kinase (Syk) inhibitor (IC= 14 nM). Has been shown to effectively inhibit FcRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC= 313 nM).

Additional Information

Synonyms	Spleen Tyrosine Kinase Inhibitor
Product #	S-2449
CAS #	622387-85-3
Chemical Name	3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
Formula	C18H15N3O3S
MW	353.39
Appearance	Orange Solid
Purity	97% by HPLC
Solubility	DMSO
Melting Point	258.51 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Syk Inhibitor is an oxindole compound that acts to effectively inhibit FcεRI-mediated degranulation in RBL-2H3. Syk Inhibitor is an inhibitor of Syk

Additional Information

MDL Number	MFCD07776820
ChemACX	X1562673-0
InChI	InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b15-8-
SMILES	Cn1cc(c2c1cccc2)/C=C\3/c4cc(ccc4NC3=O)S(=O)(=O)N