A convenient set of eight small molecule modulators useful in stem cell research. The eight modulators are: 5 mg of BIX01294, 5 mg of CHIR99021, 5 mg of PD 184352, 2 mg of PD-0325901, 10 mg of RG 108, 1 mg of SB-431542, 500 g of SU-5402, and 200 mg of Valproic Acid Sodium.