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Catharanthine is one of the alkaloids isolated from the plant Catharanthus roseus. It stimulates the release of amylase from pancreatic fragments and causes extensive degranulation of pancreatic acinar cells with accumulation of membrane material in the Golgi region. It also fully inhibits nicotinic receptor mediated diaphragm contractions (IC= 59.6 M).

Additional Information

Synonyms	Methyl (2,5,6 )-3,4-didehydroibogamine-18 -carboxylate ; 6,9-Methano-5H-pyrido[1',2':1,2]azepino[4,5-b]indole
Product #	C-2258
CAS #	2468-21-5
Chemical Name	Methyl (2ɑ,5β,6 ɑ)-3,4-didehydroibogamine-18 β -carboxylate ; 6,9-Methano-5H-pyrido[1',2':1,2]azepino[4,5-b]indole
Formula	C21H24N2O2
MW	336.43
Appearance	White crystalline Solid
Purity	98% by HPLC
Solubility	DMSO
Melting Point	126-128 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Catharanthine is a precursor of the anti-tumor drugs vinblastine and vincristin

Additional Information

MDL Number	MFCD01753356
ChemACX	X1002226-3
InChI	InChI=1S/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1
SMILES	CCC1=C[C@H]2C[C@]3([C@@H]1N(C2)CCc4c3[nH]c5c4cccc5)C(=O)OC