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Cell-permeable. A potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC= 10 nM). Displays excellent selectivity against many other kinases including Btk, Fyn, Itk, Lyn and Src up to concentrations of 4.7 M. Shows good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models.

Additional Information

Synonyms	2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl
Product #	B-2195
Chemical Name	2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide, HCl
Formula	C20H18N6O3.HCl
MW	426.86
Appearance	Yellow Solid
Purity	98% by HPLC
Solubility	Soluble in H2O (30 mg/ml) DMSO (2 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Pulmonary Disorders
Use	Spleen tyrosine kinase (Syk) inhibitor in the treatment of various allergy and asthma

Additional Information

MDL Number	MFCD28127043
ChemACX	X3036009-9
InChI	InChI=1S/C20H18N6O3.ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19;/h3-11H,1-2H3,(H2,21,27)(H,23,24,25);1H
SMILES	COC1=C(C=C(C=C1)C2=CC3=NC=CN3C(=N2)NC4=C(C=CC=N4)C(=O)N)OC.Cl