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Inhibits Stat3.Stat3 complex formation and Stat3-DNA binding activity in vitro (IC= 86 33 M) and Stat3-dependent transcriptional activities. S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors in vivo.

Additional Information

Synonyms	2-Hydroxy-4-[[[[4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid; NSC 74859; S3I-201
Product #	S-2444
CAS #	501919-59-1
Chemical Name	2-Hydroxy-4-[[[[4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid; NSC 74859; S3I-201
Formula	C16H15NO7S
MW	365.36
Appearance	Off-White Solid
Purity	97% by HPLC
Solubility	DMSO (10 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	S3I-201 inhibits the expression of the Stat3-regulated genes encoding cyclin D1, Bcl-xL, and survivin and inhibits the growth of human breast tumors

Additional Information

MDL Number	MFCD09907564
ChemACX	X1851054-4
InChI	InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
SMILES	Cc1ccc(cc1)S(=O)(=O)OCC(=O)Nc2ccc(c(c2)O)C(=O)O