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Ridaforolimus

品牌：AG Scientific

貨號：

規(guī)格：1 mg

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CAS:572924-54-0Formula:C53H84NO14PMW:990.2Appearance:WhitesolidPurity:>95%byHPLC

商品詳情參考文獻相關(guān)資料

*Please inquire the availability for this product. Ridaforolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a dimethylphosphinate moiety. Like all tacrolimus analogues, ridaforolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing its interaction with target proteins. Ridaforolimus is extensively cited in the literature with over 70 citations.

Additional Information

Synonyms	AP 23573, MK 8669, 42-Dimethylphosphinate-rapamycin
Product #	R-2597
CAS #	572924-54-0
Formula	C53H84NO14P
MW	990.2
Appearance	White solid
Purity	>95% by HPLC
Therapeutic Area	Oncological Disorders
Use	Ridaforolimus a selective FRAP (mTOR) inhibitor shows antiproliferative activity

Additional Information

MDL Number	MFCD13184816
InChI	InChI=1S/C53H84NO14P/c1-32-18-14-13-15-19-33(2)44(63-8)30-40-23-21-38(7)53(61,67-40)50(58)51(59)54-25-17-16-20-41(54)52(60)66-45(35(4)28-39-22-24-43(46(29-39)64-9)68-69(11,12)62)31-42(55)34(3)27-37(6)48(57)49(65-10)47(56)36(5)26-32/h13-15,18-19,27,32,34-36,38-41,43-46,48-49,57,61H,16-17,20-26,28-31H2,1-12H3/b15-13+,18-14+,33-19+,37-27+/t32-,34-,35-,36-,38-,39+,40+,41+,43-,44+,45+,46-,48-,49+,53-/m1/s1
SMILES	C[C@@H]1CCC2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OP(=O)(C)C)C)/C)O)OC)C)C)/C)OC

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