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*Please inquire the availability for this product. Umirolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group, providing one of most hydrophobic tacrolimus analogues. Umirolimus has been targeted for use in stents and medical devices to suppress localised immunoreaction. Like all tacrolimus analogues, umirolimus binds to receptor protein, FKBP12. The complex then binds to mTOR and prevents it from interacting with target proteins. Umirolimus is extensively cited in the literature with over 70 citations.

Additional Information

Synonyms	Biolimus, Biolimus A9, TRM 986
Product #	U-2581
CAS #	851536-75-9
Chemical Name	(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-12-((2R)-1-[(1S,3R,4R)-4-(2-ETHOXYETHOXY)-3-METHOXYCYCLOHEXYL]-2-PROPANYL)-1,18-DIHYDROXY-19,30-DIMETHOXY-15,17,21,23,29,35-HEXAMETHYL-11,36-DIO XA-4-AZATRICYCLO[30.3.1.04,9]HEXATRIACONTA-16,24,26,28
Formula	C55H87NO14
MW	986.3
Appearance	White solid
Purity	>95% by HPLC
Storage Temp	-20
Therapeutic Area	Oncological Disorders
Use	Use of umirolimus for treating cancer

Additional Information

MDL Number	MFCD22124433
InChI	InChI=1S/C55H87NO14/c1-12-67-26-27-68-45-24-22-41(31-48(45)65-10)30-37(5)47-33-44(57)36(4)29-39(7)50(59)51(66-11)49(58)38(6)28-34(2)18-14-13-15-19-35(3)46(64-9)32-42-23-21-40(8)55(63,70-42)52(60)53(61)56-25-17-16-20-43(56)54(62)69-47/h13-15,18-19,29,34,36-38,40-43,45-48,50-51,59,63H,12,16-17,20-28,30-33H2,1-11H3/b15-13+,18-14+,35-19+,39-29+/t34-,36-,37-,38-,40-,41+,42+,43+,45-,46+,47+,48-,50-,51+,55-/m1/s1
SMILES	CCOCCO[C@@H]1CC[C@H](C[C@H]1OC)C[C@@H](C)[C@@H]2CC(=O)[C@@H](/C=C(/[C@H]([C@H](C(=O)[C@@H](C[C@@H](/C=C/C=C/C=C(/[C@H](CC3CC[C@H]([C@@](O3)(C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)O)C)OC)\C)C)C)OC)O)\C)C