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TDZD-8 is a highly selective, non-ATP competitive inhibitor of GSK-3b (IC50=2M). TDZD-8 Binds to the active site of GSK3b. TDZD-8 Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50100M). Potential Alzheimer's treatment.

Additional Information

Product #	T-1132
CAS #	327036-89-5
Chemical Name	4-Benzyl-2-methyl-1,2,4,-thiadiazolidine-3,5-dione
Formula	C10H10N2SO2
MW	222.3
Appearance	Off-White Powder
Purity	95% HPLC
Solubility	DMSO
Preparation	Following reconstitution, aliquote at freeze at -20C. Stock solutions can store < 3 months at -20C.
Storage Temp	+4°C
Therapeutic Area	Neurological Disorders
Use	TDZD-8 is a highly selective, non-ATP competitive inhibitor of GSK-3b.Potential Alzheimer's treatment

Additional Information

MDL Number	MFCD04973552
ChemACX	X1437396-7
InChI	InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3
SMILES	Cn1c(=O)n(c(=O)s1)Cc2ccccc2