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Cell-permeable. A Janus Kinase 3 (JAK3) inhibitor. Displays greater antiproliferative and pro-apoptotic activity against murine multipotent factor-dependent cell Patersen-erythropoietin receptor (FDCP-EpoR) cells harboring JAK2(V617F) compared with JAK2(WT).

Additional Information

Synonyms	Tasocitinib
Product #	C-2271
CAS #	477600-75-2
Chemical Name	3-((3R,4R)-4-METHYL(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YI)AMINO)PIPERIDIN-1-YL-3-OXOPROPANENITRILE
Formula	C16H20N6O
MW	312.37
Appearance	Off-white to pale yellow Solid
Purity	99% by HPLC
Solubility	DMSO (100 mg/ml) of EtOH (100 mg/ml)
Storage Temp	-20°C
Therapeutic Area	Inflammatory Diseases
Use	The janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis

Additional Information

MDL Number	MFCD11035919
ChemACX	X1723282-5
InChI	InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1
SMILES	C[C@@H]1CCN(C[C@@H]1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N