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BIBW2992 (Afatinib)

品牌：AG Scientific

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規(guī)格：1 mg

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CAS:439081-18-2Formula:C24H25ClFN5O3MW:485.94Appearance:CrystallineSolidPurity:99%

商品詳情參考文獻(xiàn) 相關(guān)資料

BIBW-2992 is a potent irreversible EGFR/HER2 inhibitor. The potency of BIBW-2992 on the EGFR and HER2 kinases revealed ICvalues of 0.5 nM and 14 nM, respectively. BIBW-2992 is highly selective for these kinases and no additional inhibition of other kinases has been observed.

Additional Information

Synonyms	Tovok
Product #	B-2200
CAS #	439081-18-2
Chemical Name	4-[(3-CHLORO-4-FLUOROPHENYL)AMINO]-6-([4-(N,N-DIMETHYLAMINO)-1-OXO-2-BUTEN-1-YL]AMINO)-7-((S)-TETRAHYDROFURAN-3-YLOXY)-QUINAZOLINE
Formula	C₂₄H₂₅ClFN₅O₃
MW	485.94
Appearance	Crystalline Solid
Purity	99%
Solubility	DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	An irreversible and potent EGFR/Neu inhibitor, inhibits EGFR phosphorylation used in cancer

Additional Information

MDL Number	MFCD12407405
ChemACX	X1812388-7
InChI	InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
SMILES	CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4

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