17-DMAG binds to Hsp90 and alters its function. A water soluble cell-permeable analog of Geldanamycin (G-1047) and 17-AAG (A-1256), 17-DMAG binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines, and acts as angiogenesis inhibitor.Treatment with 17-DMAG significantly reduced the hemorrhage-induced increases in iNOS protein, jejunal alteration, and IL-10 concentrations, but 17-DMAG did not affect the hemorrhage-induced increases in p53 and IL-6 concentration.17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-alpha increase, and caspase-3 activation. HSP90 inhibits, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin(DMAG) to increase the radiosensitivity of tumor cells in vitro. HSP90 inhibitor, 17-DMAG, enhances radiosensitivity of human cancer cells.
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