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A potent inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC=0.69 nM). Also inhibits the growth of primary human tumor cell cultures.

Additional Information

Synonyms	6-Amino-4-[(3-bromophenyl)amino]-7-(methylamino)quinazoline
Product #	P-1651
Chemical Name	6-Amino-4-[(3-bromophenyl)amino]-7-(methylamino)quinazoline
Formula	C15H14BrN5
MW	344.2
Appearance	Yellow Solid
Purity	95%
Solubility	Soluble in DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	PD 156273 is a potent inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor use in cancer

Additional Information

MDL Number	MFCD02179206
InChI	InChI=1S/C15H14BrN5/c1-18-14-7-13-11(6-12(14)17)15(20-8-19-13)21-10-4-2-3-9(16)5-10/h2-8,18H,17H2,1H3,(H,19,20,21)
SMILES	CNc1cc2c(cc1N)c(ncn2)Nc3cccc(c3)Br