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Olaparib

品牌：AG Scientific

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規(guī)格：5 mg

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CAS:763113-22-0Formula:C24H23FN4O3MW:434.46Appearance:Whitetooff-whiteSolidPurity:98%byHPLC

商品詳情參考文獻(xiàn) 相關(guān)資料

Cell-permeable. A highly potent and selective PARP-inhibitor with ICvalues of 5 nM and 1 nM for PARP-1 and PARP-2, respectively. Olaparib displays standalone activity in BRCA-1 deficient breast cancer cells.

Additional Information

Synonyms	ADZ-2281; KU-59436
Product #	O-2371
CAS #	763113-22-0
Chemical Name	4-(3-(4-(cycloprppanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(2H)-one; ADZ-2281; KU-59436
Formula	C₂₄H₂₃FN₄O₃
MW	434.46
Appearance	White to off-white Solid
Purity	98% by HPLC
Solubility	DMSO (~33 mg/ml) or EtOH (~ 1.7 mg/ml)
Melting Point	157-170 oC
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A potent inhibitor of PARP use in cancer

Additional Information

MDL Number	MFCD13185161
ChemACX	X1812343-8
InChI	InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)
SMILES	c1ccc2c(c1)c(n[nH]c2=O)Cc3ccc(c(c3)C(=O)N4CCN(CC4)C(=O)C5CC5)F

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