A highly selective non-ATP competitive allosteric Akt inhibitor with IC50’s of 8 nM, 2 nM and 65 nM for Akt1, Akt2 and Akt3, respectively. MK-2206 potently inhibits phosphorylation of Thr3?? and Ser??3 in 3T3-L1 adipocytes with IC50 values of 0.11 and 0.18 μM, respectively as well as downstream effects of insulin on GLUT4 translocation (IC50 = 0.47 μM) and glucose transport (IC50 = 0.14 μM). In addition, treatment with MK-2206 causes a robust, concentration-dependent activation of autophagy in human glioma cell lines LN229 and T98G.
BIOLEAF熱搜 BIOLEAF試劑盒 BIOLEAF ELISA BIOLEAF試劑 BIOLEAF品牌 BIOLEAF抗體 BIOLEAF耗材 BIOLEAF小儀器
sitemap 細(xì)胞庫(kù)查詢 危險(xiǎn)品圖標(biāo) 本公司網(wǎng)站所展示銷售的產(chǎn)品僅供科研！
滬公網(wǎng)安備 31011202007338號(hào)
